Scientific Research on Green Coffee Extract

Various published weight-loss and general health-related studies which have been conducted upon green coffee bean extract.

Last updated: November 17, 2014

Weight Loss and Fat Metabolism


Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice
Pharmaceutical Research, November 2014
http://link.springer.com/article/10.1007%2Fs11095-014-1526-9

This study, conducted upon mice by researchers at the University of Georgia, provides supporting evidence that Chlorogenic Acid, a key compound found in green coffee extract, may prevent diet-induced obesity and obesity-related metabolic syndrome.

Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice
BMC Complementary and Alternative Medicine, March 17, 2006
http://www.biomedcentral.com/1472-6882/6/9

Study concluded that "GCBE can suppress body weight gain and visceral fat accumulation in mice. Caffeine suppresses fat absorption, while chlorogenic acid and its related compounds are found to be involved in the enhancement of fat metabolism in the liver." Full text.

The Use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials
Gastroenterology Research and Practice, August 10, 2010
http://www.hindawi.com/journals/grp/2011/382852/

The authors concluded that "The evidence from RCTs seems to indicate that the intake of GCE can promote weight loss", but cautioned that "size of the effect is small, and the clinical relevance of this effect is uncertain. More rigorous trials with longer duration are needed to assess the efficacy and safety of GCE as a weight loss supplement."

Lipolytic activity of SvetolĀ®, a decaffeinated green coffee bean extract.
Phytotherapy research, June, 2014
http://www.ncbi.nlm.nih.gov/pubmed/24338784

Examines the effect of the proprietary green coffee bean extract, Svetol, on the breakdown of fat (human adipocytes).

 

More Health Related Studies


Antioxidants

In vitro antioxidant and ex vivo protective activities of green and roasted coffee
Journal of agricultural and food chemistry, May, 2000
http://www.ncbi.nlm.nih.gov/pubmed/10820041


Bioavailability

Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans
The Journal of Nutrition, December 2008
http://jn.nutrition.org/content/138/12/2309.long


Cardiovascular / Hypertension

The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.
Clinical and Experimental Hypertension, July, 2006
http://www.ncbi.nlm.nih.gov/pubmed/16820341

Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects
Hypertension Research: official journal of the Japanese Society of Hypertension, June 27, 2005
http://www.nature.com/hr/journal/v28/n9/pdf/hr200591a.pdf

A multicenter, randomized, double-blind, placebo- controlled, parallel group study which evaluated the dose-response relationship of Green Coffee Extract in 117 male volunteers with mild hypertension. Full text (pdf).

Green Coffee Bean Extract Improves Human Vasoreactivity
Hypertension Research: official journal of the Japanese Society of Hypertension, March 23, 2005
https://www.jstage.jst.go.jp/article/hypres/27/10/27_10_731/_pdf

The effect of GCE on the blood vessels of 20 healthy male subjects.

Green Coffee Bean Extract and Its Metabolites Have a Hypotensive Effect in Spontaneously Hypertensive Rats
Hypertension Research: official journal of the Japanese Society of Hypertension, July 9, 2002
https://www.jstage.jst.go.jp/article/hypres/25/1/25_1_99/_pdf


Diabetes

Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice.
Evidence-Based Complementary and Alternative Medicine, April 10, 2014
http://www.hindawi.com/journals/ecam/2014/718379/

Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract.
Journal of agricultural and food chemistry, April, 2010
http://www.ncbi.nlm.nih.gov/pubmed/20302380


Metabolic Syndrome

Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet.
Archives of Biochemistry and Biophysics, Volume 559, October 2014
http://www.sciencedirect.com/science/article/pii/S0003986114000617

"In conclusion, while our study has demonstrated no positive effects of GCE supplementation on features of high-fat diet induced metabolic syndrome in mice, it cannot be ruled out that coffee or CGA will have beneficial effects in humans. To date, evidence supporting the beneficial effects of CGA remains sparse. Future studies addressing the limitations outlined in this study, as well as examining these effects in humans are warranted."


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